Short-term effects of a mandibular advancement device on obstructive sleep apnoea: an open-label pilot trial. NEW!
Obstructive sleep apnoea (OSA) is a common sleep disorder, which is, among others, associated with snoring. OSA has a considerable impact on a patient’s general health and daily life.
Oral Appliance Therapy versus Nasal Continuous Positive Airway Pressure in Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Trial. NEW!
Background: Previous randomized controlled trials have addressed the efficacy of mandibular advancement devices (MADs) in the treatment of obstructive sleep apnea (OSA).
Long-Term Follow-Up of a Randomized Controlled Trial of Oral Appliance Therapy in Obstructive Sleep Apnea. NEW!
Background: Long-term trials are needed to capture information regarding the persistence of efficacy and loss to follow-up of both mandibular advancement device (MAD) therapy and continuous positive airway pressure (CPAP) therapy.
Sleepiness in Obstructive Sleep Apnea: A Harbinger of Imparied Cardiac Function?
OBSTRUCTIVE SLEEP APNEA (OSA) IS ASSOCIATED WITH SEVERE MORBIDITY AND APPRECIABLE MORTALITY, PARTICULARLY FROM CARDIOVASCULAR diseases, hypertension, cardiac arrhythmias, stroke, and heart failure. OSA is associated with activation of a number of neural, humoral, thrombotic, metabolic, and inflammatory disease mechanisms, all of which have also been implicated in the pathophysiology of cardiac and vascular disease.
Functional Neuroimaging Insights into the Physiology of Human Sleep
Functional brain imaging has been used in humans to noninvasively investigate the neural mechanisms underlying the generation of sleep stages. One the one hand, REM sleep has been associated with thee activate of the pons, thalamus, limbic areas, and temporo-occipital cortices, and deactivation of prefrontal areas, in line with theories of REM sleep generation and dreaming properties.